Seroatlas · Human Serome Atlas

THEM6

Protein THEM6

Also known as: C8orf55, DSCD75, THEM6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUY1
Gene: THEM6
Ensembl: ENSG00000130193
Chromosome: 8
Canonical length: 208 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nuclear speckles,Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q8WUY1|THEM6
     1  MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF PGRVLPSDLD
    61  LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL AASCARHRRS LRLLEPFEVR
   121  TRLLGWDDRA FYLEARFVSL RDGFVCALLR FRQHLLGTSP ERVVQHLCQR RVEPPELPAD
   181  LQHWISYNEA SSQLLRMESG LSDVTKDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THEM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

liver: 47 nTPM
pancreas: 22 nTPM
kidney: 21 nTPM
esophagus: 20 nTPM
cerebral cortex: 19 nTPM
adrenal gland: 17 nTPM

Single-cell type

breast lactating cells: 76 nCPM
urothelial cells: 51 nCPM
esophageal suprabasal cells: 49 nCPM
esophageal basal cells: 45 nCPM
breast myoepithelial cells: 45 nCPM
lymphatic endothelial cells: 43 nCPM

Immune cell

MAIT T-cell: 17 nTPM
memory CD8 T-cell: 14 nTPM
naive CD4 T-cell: 14 nTPM
naive CD8 T-cell: 13 nTPM
memory CD4 T-cell: 12 nTPM
T-reg: 12 nTPM

Brain region

medulla oblongata: 35 nTPM
cerebral cortex: 29 nTPM
midbrain: 29 nTPM
pons: 27 nTPM
hippocampal formation: 25 nTPM
thalamus: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about THEM6.

Disease | ImmuneIEDB

Conditions an epitope on THEM6 was assayed in.

psoriasis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0.05
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

HotDog domain superfamily
THEM6/lcsJ thioesterase
Thioesterase-like superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THEM6 as an antibody target. Whether an autoantibody or antibody against THEM6 could matter depends on whether native THEM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THEM6 is annotated as secreted, so native THEM6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label THEM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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