THEM5
Acyl-coenzyme A thioesterase THEM5
Also known as: FLJ37964, THEM5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N1Q8
- Gene
- THEM5
- Ensembl
- ENSG00000196407
- Chromosome
- 1
- Canonical length
- 247 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables long-chain fatty acyl-CoA hydrolase activity. Involved in long-chain fatty-acyl-CoA metabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
247 residues, UniProt reviewed canonical sequence.
>Q8N1Q8|THEM5
1 MIRRCFQVAA RLGHHRGLLE APRILPRLNP ASAFGSSTDS MFSRFLPEKT DLKDYALPNA
61 SWCSDMLSLY QEFLEKTKSS GWIKLPSFKS NRDHIRGLKL PSGLAVSSDK GDCRIFTRCI
121 QVEGQGFEYV IFFQPTQKKS VCLFQPGSYL EGPPGFAHGG SLAAMMDETF SKTAFLAGEG
181 LFTLSLNIRF KNLIPVDSLV VMDVELDKIE DQKLYMSCIA HSRDQQTVYA KSSGVFLQLQ
241 LEEESPQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against THEM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 138 nTPM
Expression across tissuesHPA
Tissue
- skin: 138 nTPM
- esophagus: 6.1 nTPM
- lymph node: 5.9 nTPM
- breast: 3.9 nTPM
- cerebral cortex: 3.8 nTPM
- cervix: 3.1 nTPM
Single-cell type
- suprabasal keratinocytes: 81 nCPM
- platelets: 68 nCPM
- adrenal medulla cells: 11 nCPM
- esophageal suprabasal cells: 7.7 nCPM
- megakaryocytes: 6.2 nCPM
- basal keratinocytes: 6.1 nCPM
Immune cell
- MAIT T-cell: 1.7 nTPM
- total PBMC: 1.7 nTPM
- T-reg: 0.9 nTPM
- gdT-cell: 0.7 nTPM
- memory CD4 T-cell: 0.6 nTPM
- memory CD8 T-cell: 0.4 nTPM
Brain region
- cerebral cortex: 20 nTPM
- amygdala: 15 nTPM
- white matter: 13 nTPM
- pons: 10 nTPM
- hippocampal formation: 10 nTPM
- medulla oblongata: 9.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads THEM5 as an antibody target. Whether an autoantibody or antibody against THEM5 could matter depends on whether native THEM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
THEM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label THEM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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