Seroatlas · Human Serome Atlas

THEM4

Acyl-coenzyme A thioesterase THEM4

Also known as: CTMP, THEM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1C6
Gene: THEM4
Ensembl: ENSG00000159445
Chromosome: 1
Canonical length: 240 aa
Protein class: Enzymes, Predicted intracellular proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q5T1C6|THEM4
     1  MLRSCAARLR TLGALCLPPV GRRLPGSEPR PELRSFSSEE VILKDCSVPN PSWNKDLRLL
    61  FDQFMKKCED GSWKRLPSYK RTPTEWIQDF KTHFLDPKLM KEEQMSQAQL FTRSFDDGLG
   121  FEYVMFYNDI EKRMVCLFQG GPYLEGPPGF IHGGAIATMI DATVGMCAMM AGGIVMTANL
   181  NINYKRPIPL CSVVMINSQL DKVEGRKFFV SCNVQSVDEK TLYSEATSLF IKLNPAKSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THEM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

retina: 18 nTPM
skeletal muscle: 10 nTPM
parathyroid gland: 8 nTPM
kidney: 7.5 nTPM
epididymis: 6.7 nTPM
pancreas: 6.4 nTPM

Single-cell type

adrenal cortex cells: 126 nCPM
renal collecting duct intercalated cells: 114 nCPM
rod photoreceptor cells: 98 nCPM
myonuclei: 98 nCPM
hematopoietic stem cells: 90 nCPM
sertoli cells: 75 nCPM

Immune cell

T-reg: 22 nTPM
naive CD4 T-cell: 15 nTPM
memory CD4 T-cell: 15 nTPM
MAIT T-cell: 11 nTPM
naive CD8 T-cell: 11 nTPM
NK-cell: 7.9 nTPM

Brain region

white matter: 24 nTPM
cerebellum: 24 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 23 nTPM
pons: 22 nTPM
thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

long-chain fatty acyl-CoA hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THEM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AKT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THEM4 as an antibody target. Whether an autoantibody or antibody against THEM4 could matter depends on whether native THEM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THEM4 is annotated at the cell surface, where native THEM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label THEM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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