Seroatlas · Human Serome Atlas

THAP9

DNA transposase THAP9

Also known as: FLJ34093, THAP9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H5L6
Gene
THAP9
Ensembl
ENSG00000168152
Chromosome
4
Canonical length
903 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables sequence-specific DNA binding activity and transposase activity. Involved in DNA integration and DNA transposition. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q9H5L6|THAP9
     1  MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK KIWIPGPGAI
    61  LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK GKARQKILKQ PLPDNSQEVA
   121  TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK KRLISVKNYR MIKKRKGLRL IDALVEEKLL
   181  SEETECLLRA QFSDFKWELY NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS
   241  ILRTWLSKCQ PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ
   301  GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ AQLLRLTIGK
   361  LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ HPSSSSQQIA YFFDSCHLLR
   421  LIRNAFQNFQ SIQFINGIAH WQHLVELVAL EEQELSNMER IPSTLANLKN HVLKVNSATQ
   481  LFSESVASAL EYLLSLDLPP FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY
   541  SKINHVLIEA KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP
   601  YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE VFLSKVSIFD
   661  ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS LSEALLDLSD HRRNLICYAG
   721  YVANKLSALL TCEDCITALY ASDLKASKIG SLLFVKKKNG LHFPSESLCR VINICERVVR
   781  THSRMAIFEL VSKQRELYLQ QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII
   841  ICFLNIRAKN VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY
   901  PFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 6.4 nTPM
  • testis: 6.3 nTPM
  • skeletal muscle: 4.8 nTPM
  • retina: 4 nTPM
  • thyroid gland: 3.9 nTPM
  • epididymis: 3.4 nTPM

Single-cell type

  • late spermatids: 81 nCPM
  • neutrophils: 69 nCPM
  • early spermatids: 66 nCPM
  • myonuclei: 41 nCPM
  • enterocytes: 34 nCPM
  • innate lymphoid cells: 28 nCPM

Immune cell

  • intermediate monocyte: 1.4 nTPM
  • memory B-cell: 1.3 nTPM
  • naive CD4 T-cell: 1.2 nTPM
  • naive B-cell: 1.1 nTPM
  • myeloid DC: 1 nTPM
  • naive CD8 T-cell: 1 nTPM

Brain region

  • white matter: 9.2 nTPM
  • medulla oblongata: 4.9 nTPM
  • basal ganglia: 4.8 nTPM
  • cerebellum: 4.4 nTPM
  • hypothalamus: 4.3 nTPM
  • pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
1.44
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

  • THAP-type zinc finger
  • THAP-type zinc finger superfamily
  • THAP domain
  • THAP9-like, helix-turn-helix domain
  • Transposable element P transposase-like, RNase H domain, N-terminal
  • Transposable element P transposase-like, GTP-binding insertion domain
  • Transposable element P transposase-like, RNase H, C-terminal domain
  • DNA transposase THAP9, C-terminal domain
  • Transposable element P transposase-like, HTH domain
  • TNP-like, RNase H N-terminal domain
  • TNP-like, GTP-binding insertion domain
  • TNP-like, RNase H C-terminal domain
  • DNA transposase THAP9, C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP9 as an antibody target. Whether an autoantibody or antibody against THAP9 could matter depends on whether native THAP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THAP9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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