THAP8
THAP domain-containing protein 8
Also known as: FLJ32891, THAP8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NA92
- Gene
- THAP8
- Ensembl
- ENSG00000161277
- Chromosome
- 19
- Canonical length
- 274 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
274 residues, UniProt reviewed canonical sequence.
>Q8NA92|THAP8
1 MPKYCRAPNC SNTAGRLGAD NRPVSFYKFP LKDGPRLQAW LQHMGCEHWV PSCHQHLCSE
61 HFTPSCFQWR WGVRYLRPDA VPSIFSRGPP AKSQRRTRST QKPVSPPPPL QKNTPLPQSP
121 AIPVSGPVRL VVLGPTSGSP KTVATMLLTP LAPAPTPERS QPEVPAQQAQ TGLGPVLGAL
181 QRRVRRLQRC QERHQAQLQA LERLAQQLHG ESLLARARRG LQRLTTAQTL GPEESQTFTI
241 ICGGPDIAMV LAQDPAPATV DAKPELLDTR IPSALocalizationUniProt · AlphaFold · HPA
Whether an antibody against THAP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- colon: 14 nTPM
- testis: 11 nTPM
- spinal cord: 11 nTPM
- urinary bladder: 10 nTPM
- midbrain: 9.7 nTPM
- skeletal muscle: 9.5 nTPM
Single-cell type
- oocytes: 46 nCPM
- early primary spermatocytes: 26 nCPM
- differentiating spermatogonia: 25 nCPM
- hofbauer cells: 23 nCPM
- undifferentiated spermatogonia: 21 nCPM
- esophageal apical cells: 20 nCPM
Immune cell
- eosinophil: 7.9 nTPM
- intermediate monocyte: 7.6 nTPM
- basophil: 7.1 nTPM
- non-classical monocyte: 6.6 nTPM
- classical monocyte: 6.5 nTPM
- naive CD8 T-cell: 6.2 nTPM
Brain region
- white matter: 14 nTPM
- medulla oblongata: 13 nTPM
- midbrain: 12 nTPM
- hypothalamus: 11 nTPM
- pons: 11 nTPM
- thalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.09
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads THAP8 as an antibody target. Whether an autoantibody or antibody against THAP8 could matter depends on whether native THAP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
THAP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label THAP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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