Seroatlas · Human Serome Atlas

THAP7

THAP domain-containing protein 7

Also known as: MGC10963, THAP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT49
Gene: THAP7
Ensembl: ENSG00000184436
Chromosome: 22
Canonical length: 309 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables several functions, including C2H2 zinc finger domain binding activity; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Located in chromatin; nuclear membrane; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9BT49|THAP7
     1  MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG QGLWDPASEY
    61  IYFCSKHFEE DCFELVGISG YHRLKEGAVP TIFESFSKLR RTTKTKGHSY PPGPAEVSRL
   121  RRCRKRCSEG RGPTTPFSPP PPADVTCFPV EEASAPATLP ASPAGRLEPG LSSPFSDLLG
   181  PLGAQADEAG CSAQPSPERQ PSPLEPRPVS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW
   241  KRRAEAALDA LDKAQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKEHVQDF
   301  AMQLSSSMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 38 nTPM
skeletal muscle: 37 nTPM
liver: 37 nTPM
testis: 34 nTPM
prostate: 28 nTPM
choroid plexus: 26 nTPM

Single-cell type

early primary spermatocytes: 206 nCPM
differentiating spermatogonia: 73 nCPM
oocytes: 69 nCPM
late spermatids: 63 nCPM
late primary spermatocytes: 57 nCPM
gastric chief cells: 56 nCPM

Immune cell

memory B-cell: 50 nTPM
naive CD4 T-cell: 45 nTPM
naive B-cell: 37 nTPM
naive CD8 T-cell: 36 nTPM
MAIT T-cell: 36 nTPM
memory CD4 T-cell: 33 nTPM

Brain region

choroid plexus: 16 nTPM
midbrain: 15 nTPM
pons: 13 nTPM
medulla oblongata: 12 nTPM
thalamus: 12 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.01
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

THAP-type zinc finger
THAP domain
THAP domain-containing protein 7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THAP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP7 as an antibody target. Whether an autoantibody or antibody against THAP7 could matter depends on whether native THAP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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