Seroatlas · Human Serome Atlas

THAP6

THAP domain-containing protein 6

Also known as: MGC30052, THAP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBB0
Gene: THAP6
Ensembl: ENSG00000174796
Chromosome: 4
Canonical length: 222 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in endothelial cell proliferation and regulation of DNA-templated transcription. Located in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q8TBB0|THAP6
     1  MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA GIWEPKKGDV
    61  LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE KLHCRKNFTL KTVPATNYNH
   121  HLVGASSCIE EFQSQFIFEH SYSVMDSPKK LKHKLDHVIG ELEDTKESLR NVLDREKRFQ
   181  KSLRKTIREL KDECLISQET ANRLDTFCWD CCQESIEQDY IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
retina: 20 nTPM
skin: 16 nTPM
endometrium: 15 nTPM
lymph node: 15 nTPM
skeletal muscle: 15 nTPM

Single-cell type

early spermatids: 175 nCPM
cardiomyocytes: 127 nCPM
late primary spermatocytes: 105 nCPM
tuft cells: 69 nCPM
oligodendrocytes: 61 nCPM
bergmann glia: 61 nCPM

Immune cell

neutrophil: 18 nTPM
basophil: 17 nTPM
T-reg: 14 nTPM
eosinophil: 13 nTPM
MAIT T-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM

Brain region

white matter: 65 nTPM
cerebellum: 53 nTPM
basal ganglia: 48 nTPM
medulla oblongata: 48 nTPM
hypothalamus: 47 nTPM
pons: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

microtubule cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP6 as an antibody target. Whether an autoantibody or antibody against THAP6 could matter depends on whether native THAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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