Seroatlas · Human Serome Atlas

THAP3

THAP domain-containing protein 3

Also known as: THAP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTV1
Gene: THAP3
Ensembl: ENSG00000041988
Chromosome: 1
Canonical length: 239 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q8WTV1|THAP3
     1  MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR
    61  PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE RGNASSSQKE KVLPEAGAGE
   121  DSPGRNMDTA LEELQLPPNA EGHVKQVSPR RPQATEAVGR PTGPAGLRRT PNKQPSDHSY
   181  ALLDLDSLKK KLFLTLKENE KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

kidney: 31 nTPM
liver: 27 nTPM
cerebellum: 27 nTPM
heart muscle: 27 nTPM
adrenal gland: 24 nTPM
hippocampal formation: 24 nTPM

Single-cell type

cardiomyocytes: 36 nCPM
late primary spermatocytes: 34 nCPM
undifferentiated spermatogonia: 25 nCPM
decidual stromal cells: 23 nCPM
breast myoepithelial cells: 22 nCPM
differentiating spermatogonia: 21 nCPM

Immune cell

naive B-cell: 31 nTPM
naive CD4 T-cell: 27 nTPM
T-reg: 27 nTPM
memory CD8 T-cell: 27 nTPM
MAIT T-cell: 26 nTPM
gdT-cell: 25 nTPM

Brain region

white matter: 24 nTPM
medulla oblongata: 23 nTPM
cerebellum: 21 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 19 nTPM
amygdala: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.01
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of transcription by RNA polymerase II

Molecular functions

Protein domainsUniProt · Pfam · InterPro

THAP-type zinc finger
THAP domain
THAP domain-containing protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP3 as an antibody target. Whether an autoantibody or antibody against THAP3 could matter depends on whether native THAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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