Seroatlas · Human Serome Atlas

THAP2

THAP domain-containing protein 2

Also known as: DKFZP564I0422, THAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0W7
Gene: THAP2
Ensembl: ENSG00000173451
Chromosome: 12
Canonical length: 228 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q9H0W7|THAP2
     1  MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT FLCSKHFEAS
    61  CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN NSCSPAGPSN LKSNISSQQV
   121  LLEHSYAFRN PMEAKKRIIK LEKEIASLRR KMKTCLQKER RATRRWIKAT CLVKNLEANS
   181  VLPKGTSEHM LPTALSSLPL EDFKILEQDQ QDKTLLSLNL KQTKSTFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 28 nTPM
urinary bladder: 26 nTPM
testis: 17 nTPM
epididymis: 16 nTPM
adipose tissue: 15 nTPM
bone marrow: 14 nTPM

Single-cell type

monocytes: 108 nCPM
early spermatids: 94 nCPM
late spermatids: 84 nCPM
vascular smooth muscle cells: 53 nCPM
mast cells: 50 nCPM
epididymal basal cells: 46 nCPM

Immune cell

naive CD4 T-cell: 8.1 nTPM
NK-cell: 6.4 nTPM
MAIT T-cell: 6.1 nTPM
naive CD8 T-cell: 5.5 nTPM
T-reg: 5.5 nTPM
memory CD4 T-cell: 5.1 nTPM

Brain region

cerebellum: 25 nTPM
white matter: 22 nTPM
cerebral cortex: 16 nTPM
basal ganglia: 16 nTPM
spinal cord: 15 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP2 as an antibody target. Whether an autoantibody or antibody against THAP2 could matter depends on whether native THAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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