Seroatlas · Human Serome Atlas

THAP10

THAP domain-containing protein 10

Also known as: THA10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2Z0
Gene: THAP10
Ensembl: ENSG00000129028
Chromosome: 15
Canonical length: 257 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q9P2Z0|THAP10
     1  MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR SVICSDHFAP
    61  ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG EEGDQAGRLD TRGELQAARH
   121  SEAAPGPVSC TRPRAGKQAA ASQITCENEL VQTQPHADNP SNTVTSVPTH CEEGPVHKST
   181  QISLKRPRHR SVGIQAKVKA FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS
   241  EQSDLSYMAV QVKEETC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
cerebellum: 7.8 nTPM
cerebral cortex: 7.2 nTPM
spinal cord: 7.2 nTPM
hypothalamus: 6 nTPM
basal ganglia: 5.8 nTPM

Single-cell type

parietal cells: 46 nCPM
oocytes: 32 nCPM
epicardial cells: 30 nCPM
late primary spermatocytes: 27 nCPM
retinal bipolar cells: 15 nCPM
respiratory ciliated cells: 9.7 nCPM

Immune cell

non-classical monocyte: 4.2 nTPM
myeloid DC: 0.6 nTPM
intermediate monocyte: 0.5 nTPM
NK-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM
memory B-cell: 0.3 nTPM

Brain region

thalamus: 11 nTPM
cerebral cortex: 10 nTPM
cerebellum: 10 nTPM
white matter: 9.6 nTPM
midbrain: 8.8 nTPM
pons: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.05
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP10 as an antibody target. Whether an autoantibody or antibody against THAP10 could matter depends on whether native THAP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...