Seroatlas · Human Serome Atlas

THADA

tRNA (32-2'-O)-methyltransferase regulator THADA

Also known as: ARMC13, FLJ21877, GITA, KIAA1767, THADA_HUMAN, Trm732

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6YHU6
Gene
THADA
Ensembl
ENSG00000115970
Chromosome
2
Canonical length
1953 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

1953 residues, UniProt reviewed canonical sequence.

>Q6YHU6|THADA
     1  MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP
    61  LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS
   121  RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC
   181  AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD
   241  DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG
   301  DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL
   361  ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ
   421  MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ
   481  ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD
   541  QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC
   601  LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM
   661  QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH
   721  PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS
   781  HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST
   841  KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL
   901  EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE KLLLMSYRLS
   961  TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL KEHDSFDMKD
  1021  LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL LPMQPVPESS
  1081  DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW
  1141  SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD
  1201  IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR NSSTLLFSAL
  1261  ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL ETVANTVDSD MGEPNRHPSM
  1321  FLLLLVLERL YASPMDGTSS ALSMGPFVPF IMRCGHSPVY HSREMAARAL VPFVMIDHIP
  1381  NTIRTLLSTL PSCTDQCFRQ NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK
  1441  AKLWLAKRQN PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI
  1501  TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE SAFPEVRSLT
  1561  LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH PECFCKILKI LHCMDPGEWL
  1621  PQTEHCVHLT PKEFLIWTMD IASNERSEIQ SVALRLASKV ISHHMQTCVE NRELIAAELK
  1681  QWVQLVILSC EDHLPTESRL AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE
  1741  EQAVRDAATE TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP
  1801  ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH LFCLLSKSGW
  1861  RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE FTRLRIQEER TLACLRLLAF
  1921  LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE AAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THADA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 16 nTPM
  • liver: 16 nTPM
  • lymph node: 13 nTPM
  • skin: 13 nTPM
  • thyroid gland: 13 nTPM
  • prostate: 13 nTPM

Single-cell type

  • choroid plexus epithelial cells: 335 nCPM
  • ependymal cells: 335 nCPM
  • lactotrophs: 327 nCPM
  • respiratory ciliated cells: 278 nCPM
  • pituicytes/fscs: 270 nCPM
  • somatotrophs: 264 nCPM

Immune cell

  • basophil: 18 nTPM
  • NK-cell: 5.4 nTPM
  • T-reg: 4.5 nTPM
  • myeloid DC: 4.2 nTPM
  • memory CD8 T-cell: 4.1 nTPM
  • intermediate monocyte: 4 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 14 nTPM
  • midbrain: 13 nTPM
  • thalamus: 13 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
-2.96
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Armadillo-type fold
  • THADA/TRM732, DUF2428
  • tRNA (32-2'-O)-methyltransferase regulator THADA
  • tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region
  • tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region
  • THADA/TRM732, DUF2428
  • Trm732, TPR repeats
  • Trm732, C-terminal TPR repeats

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THADA as an antibody target. Whether an autoantibody or antibody against THADA could matter depends on whether native THADA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THADA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THADA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THADA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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