Seroatlas · Human Serome Atlas

TGOLN2

Trans-Golgi network integral membrane protein 2

Also known as: TGN38, TGN46, TGN48, TGN51, TGON2_HUMAN, TTGN2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43493
Gene: TGOLN2
Ensembl: ENSG00000152291
Chromosome: 2
Canonical length: 437 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>O43493|TGOLN2
     1  MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP GGSTKSHPEP
    61  QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA EAKTQKGSTS KSGSEAQTTK
   121  DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN
   181  KSGADGQTPK DGSSKSGAED QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA
   241  EEQTSKDSPN KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE
   301  ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA SSENREGTLS
   361  DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY IAHHNKRKII AFVLEGKRSK
   421  VTRRPKASDY QRLDQKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGOLN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

liver: 128 nTPM
bone marrow: 123 nTPM
kidney: 113 nTPM
small intestine: 106 nTPM
duodenum: 105 nTPM
rectum: 96 nTPM

Single-cell type

hepatocytes: 284 nCPM
neutrophils: 280 nCPM
neutrophil progenitors: 253 nCPM
kupffer cells: 251 nCPM
monocytes: 209 nCPM
platelets: 201 nCPM

Immune cell

non-classical monocyte: 104 nTPM
neutrophil: 97 nTPM
classical monocyte: 78 nTPM
total PBMC: 76 nTPM
intermediate monocyte: 73 nTPM
eosinophil: 69 nTPM

Brain region

white matter: 129 nTPM
medulla oblongata: 122 nTPM
cerebral cortex: 122 nTPM
hypothalamus: 119 nTPM
thalamus: 119 nTPM
midbrain: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Keratinocyte-associated gene product

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TGOLN2 as an antibody target. Whether an autoantibody or antibody against TGOLN2 could matter depends on whether native TGOLN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TGOLN2 is annotated at the cell surface, where native TGOLN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TGOLN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...