TGM7

Protein identityUniProt · HPA

UniProt accession

Q96PF1

Gene

TGM7

Ensembl

ENSG00000159495

Chromosome

15

Canonical length

710 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q96PF1|TGM7
     1  MDQVATLRLE SVDLQSSRNN KEHHTQEMGV KRLTVRRGQP FYLRLSFSRP FQSQNDHITF
    61  VAETGPKPSE LLGTRATFFL TRVQPGNVWS ASDFTIDSNS LQVSLFTPAN AVIGHYTLKI
   121  EISQGQGHSV TYPLGTFILL FNPWSPEDDV YLPSEILLQE YIMRDYGFVY KGHERFITSW
   181  PWNYGQFEED IIDICFEILN KSLYHLKNPA KDCSQRNDVV YVCRVVSAMI NSNDDNGVLQ
   241  GNWGEDYSKG VSPLEWKGSV AILQQWSARG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
   301  SNFRSAHNVD RNLTIDTYYD RNAEMLSTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL
   361  DPTPQQTSSG LFCCGPASVK AIREGDVHLA YDTPFVYAEV NADEVIWLLG DGQAQEILAH
   421  NTSSIGKEIS TKMVGSDQRQ SITSSYKYPE GSPEERAVFM KASRKMLGPQ RASLPFLDLL
   481  ESGGLRDQPA QLQLHLARIP EWGQDLQLLL RIQRVPDSTH PRGPIGLVVR FCAQALLHGG
   541  GTQKPFWRHT VRMNLDFGKE TQWPLLLPYS NYRNKLTDEK LIRVSGIAEV EETGRSMLVL
   601  KDICLEPPHL SIEVSERAEV GKALRVHVTL TNTLMVALSS CTMVLEGSGL INGQIAKDLG
   661  TLVAGHTLQI QLDLYPTKAG PRQLQVLISS NEVKEIKGYK DIFVTVAGAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

1.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0

gnomAD missense Z

0.03

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• metal ion binding
• protein-glutamine gamma-glutamyltransferase activity

Protein domainsUniProt · Pfam · InterPro

• Transglutaminase, N-terminal
• Transglutaminase-like
• Transglutaminase, C-terminal
• Immunoglobulin-like fold
• Transglutaminase, active site
• Immunoglobulin E-set
• Protein-glutamine gamma-glutamyltransferase, animal
• Transglutaminase, C-terminal domain superfamily
• Transglutaminase-like superfamily
• Papain-like cysteine peptidase superfamily
• Protein-glutamine gamma-glutamyltransferases
• Transglutaminase family
• Transglutaminase family, C-terminal ig like domain
• Transglutaminase-like superfamily

KeywordsUniProt

• Acyltransferase
• Calcium
• Metal-binding
• Transferase