Seroatlas · Human Serome Atlas

TGM4

Protein-glutamine gamma-glutamyltransferase 4

Also known as: TGM4_HUMAN, TGP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49221
Gene: TGM4
Ensembl: ENSG00000163810
Chromosome: 3
Canonical length: 684 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to act upstream of or within mating plug formation. Located in Golgi apparatus and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>P49221|TGM4
     1  MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL
    61  EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE VTVAVTSSPN AILGKYQLNV
   121  KTGNHILKSE ENILYLLFNP WCKEDMVFMP DEDERKEYIL NDTGCHYVGA ARSIKCKPWN
   181  FGQFEKNVLD CCISLLTESS LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG
   241  TAPYKWTGSA PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER
   301  NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD ATPQERSQGV
   361  FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM VNGQEELHVI SMETTSIGKN
   421  ISTKAVGQDR RRDITYEYKY PEGSSEERQV MDHAFLLLSS EREHRRPVKE NFLHMSVQSD
   481  DVLLGNSVNF TVILKRKTAA LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT
   541  LTLDSKTYIN SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG
   601  QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI KCTPIKTGPK
   661  KFIVKLSSKQ VKEINAQKIV LITK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 768 nTPM

Expression across tissuesHPA

Tissue

prostate: 768 nTPM
adrenal gland: 2.2 nTPM
epididymis: 1.6 nTPM
testis: 1 nTPM
appendix: 0.6 nTPM
bone marrow: 0.5 nTPM

Single-cell type

late spermatids: 12 nCPM
prostatic glandular cells: 10 nCPM
prostatic club cells: 2.3 nCPM
early spermatids: 1.8 nCPM
prostatic hillock cells: 0.7 nCPM
papillary tip epithelial cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.5 nTPM
cerebral cortex: 0.4 nTPM
choroid plexus: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
hippocampal formation: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TGM4.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Essential tremor

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TGM4 as an antibody target. Whether an autoantibody or antibody against TGM4 could matter depends on whether native TGM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TGM4 is annotated as secreted, so native TGM4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TGM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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