TFCP2L1

Protein identityUniProt · HPA

UniProt accession

Q9NZI6

Gene

TFCP2L1

Ensembl

ENSG00000115112

Chromosome

2

Canonical length

479 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoli fibrillar center,Mitochondria

Quaternary structure

Homohexamer

OverviewNCBI Gene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9NZI6|TFCP2L1
     1  MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV LCAATSPAVK
    61  LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII RVVFHDRRLQ YTEHQQLEGW
   121  RWSRPGDRIL DIDIPLSVGI LDPRASPTQL NAVEFLWDPA KRASAFIQVH CISTEFTPRK
   181  HGGEKGVPFR VQIDTFKQNE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ
   241  EKEKYQPSYE TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV
   301  GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC GPADGIRLFN
   361  AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV YHAIFLEELT TLELIEKIAN
   421  LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ NFQDESCFVL STIKAESNDG YHIILKCGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFCP2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

92 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TFCP2L1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Chronic kidney disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

gnomAD missense Z

1.63

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell morphogenesis
• cytoplasm organization
• determination of adult lifespan
• epithelial cell maturation
• negative regulation of transcription by RNA polymerase II
• positive regulation of growth
• regulation of transcription by RNA polymerase II
• salivary gland development

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytoplasm
• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• CP2 transcription factor
• Sterile alpha motif/pointed domain superfamily
• Transcription factor CP2-like
• SAM domain
• GRHL1/CP2, C-terminal domain
• CP2 transcription factor
• SAM domain (Sterile alpha motif)
• GRHL1-like, C-terminal domain
• TFCP2L1, SAM domain

KeywordsUniProt

• DNA-binding
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TFCP2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MTA1