Seroatlas · Human Serome Atlas

TFB2M

Dimethyladenosine transferase 2, mitochondrial

Also known as: FLJ22661, FLJ23182, Hkp1, TFB2M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5Q4
Gene: TFB2M
Ensembl: ENSG00000162851
Chromosome: 1
Canonical length: 396 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables mitochondrial transcription factor activity. Involved in transcription initiation at mitochondrial promoter. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q9H5Q4|TFB2M
     1  MWIPVVGLPR RLRLSALAGA GRFCILGSEA ATRKHLPARN HCGLSDSSPQ LWPEPDFRNP
    61  PRKASKASLD FKRYVTDRRL AETLAQIYLG KPSRPPHLLL ECNPGPGILT QALLEAGAKV
   121  VALESDKTFI PHLESLGKNL DGKLRVIHCD FFKLDPRSGG VIKPPAMSSR GLFKNLGIEA
   181  VPWTADIPLK VVGMFPSRGE KRALWKLAYD LYSCTSIYKF GRIEVNMFIG EKEFQKLMAD
   241  PGNPDLYHVL SVIWQLACEI KVLHMEPWSS FDIYTRKGPL ENPKRRELLD QLQQKLYLIQ
   301  MIPRQNLFTK NLTPMNYNIF FHLLKHCFGR RSATVIDHLR SLTPLDARDI LMQIGKQEDE
   361  KVVNMHPQDF KTLFETIERS KDCAYKWLYD ETLEDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFB2M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

liver: 35 nTPM
bone marrow: 23 nTPM
tongue: 23 nTPM
skeletal muscle: 22 nTPM
adrenal gland: 22 nTPM
kidney: 20 nTPM

Single-cell type

oocytes: 83 nCPM
basal keratinocytes: 60 nCPM
gastric progenitor cells: 58 nCPM
endometrial glandular cells: 53 nCPM
suprabasal keratinocytes: 44 nCPM
differentiating spermatogonia: 43 nCPM

Immune cell

NK-cell: 15 nTPM
myeloid DC: 13 nTPM
T-reg: 12 nTPM
naive B-cell: 12 nTPM
memory B-cell: 12 nTPM
MAIT T-cell: 12 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 11 nTPM
cerebral cortex: 6.7 nTPM
white matter: 6.7 nTPM
hypothalamus: 6.5 nTPM
spinal cord: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFB2M in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFB2M as an antibody target. Whether an autoantibody or antibody against TFB2M could matter depends on whether native TFB2M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFB2M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TFB2M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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