Seroatlas · Human Serome Atlas

TFAP2E

Transcription factor AP-2-epsilon

Also known as: AP-2epsilon, AP2E, AP2E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6VUC0
Gene: TFAP2E
Ensembl: ENSG00000116819
Chromosome: 1
Canonical length: 442 aa
Protein class: Predicted intracellular proteins, Transcription factors
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q6VUC0|TFAP2E
     1  MLVHTYSAME RPDGLGAAAG GARLSSLPQA AYGPAPPLCH TPAATAAAEF QPPYFPPPYP
    61  QPPLPYGQAP DAAAAFPHLA GDPYGGLAPL AQPQPPQAAW AAPRAAARAH EEPPGLLAPP
   121  ARALGLDPRR DYATAVPRLL HGLADGAHGL ADAPLGLPGL AAAPGLEDLQ AMDEPGMSLL
   181  DQSVIKKVPI PSKASSLSAL SLAKDSLVGG ITNPGEVFCS VPGRLSLLSS TSKYKVTVGE
   241  VQRRLSPPEC LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV
   301  EGEAVHLARD FGYVCETEFP AKAAAEYLCR QHADPGELHS RKSMLLAAKQ ICKEFADLMA
   361  QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA ALTAFQNYLL ESLKGLDKMF
   421  LSSVGSGHGE TKASEKDAKH RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFAP2E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.7 nTPM
retina: 3.2 nTPM
bone marrow: 1.4 nTPM
skin: 1.4 nTPM
basal ganglia: 1.2 nTPM
cerebral cortex: 1.2 nTPM

Single-cell type

retinal bipolar cells: 73 nCPM
retinal amacrine cells: 70 nCPM
rod photoreceptor cells: 33 nCPM
retinal ganglion cells: 27 nCPM
retinal horizontal cells: 20 nCPM
brain inhibitory neurons: 18 nCPM

Immune cell

gdT-cell: 0.9 nTPM
NK-cell: 0.9 nTPM
classical monocyte: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM
T-reg: 0.8 nTPM

Brain region

cerebellum: 19 nTPM
white matter: 11 nTPM
cerebral cortex: 8.2 nTPM
pons: 7.4 nTPM
basal ganglia: 7.1 nTPM
medulla oblongata: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFAP2E as an antibody target. Whether an autoantibody or antibody against TFAP2E could matter depends on whether native TFAP2E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFAP2E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TFAP2E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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