Seroatlas · Human Serome Atlas

TEX55

Testis-specific expressed protein 55

Also known as: C3orf30, FLJ32859, TEX55_HUMAN, TSCPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M34
Gene: TEX55
Ensembl: ENSG00000163424
Chromosome: 3
Canonical length: 536 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>Q96M34|TEX55
     1  MEEPPQEALA EPLKHESPAA PSSAGHTKGQ EEDDQKNQAE RKADNHTAHR IADQTALRVP
    61  SQAESSIFSQ ATNGVAEQNG HSTPGQAGRR ASNPADVSDL RADDQVNQTP SEQTKGKASS
   121  QANNVQHEQS DGQVSGLTEE RTAEQTERRL PTQAERRTSG QIDGRLAMPS DQRGSRQTDH
   181  RMAGQSERRA SEQMDRRMSG EAERRTSEQI THRLSKLSER RPSVQIDSGS SVPSDQSPSV
   241  QIDSGSSVPS DQRPSVQIDR RMSGKVRRRS SEKTDYRLAG LADPGTSEQT DLRLYGLVDH
   301  KTSVKTHHQV YGQATELAEH QAIDQAHSNA DQPPVDNAHY TESDQTDHLA DRQANHKDQL
   361  SYYETRGQSE DRIFPQLGNS KEDKEADYRV QPCKFEDSQV DLNSKPSVEM ETQNATTIPP
   421  YNPVDARFTS NFQAKDQALF PRLPSISSKL NYTSSQEKTQ AIVTKSDEFS EIDQGKGYHI
   481  RNQTYRRFPS IVYEDPYQVS LQYMEKHHIL QIFQQITENL VYEKPEDPLN FMLCQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

testis: 50 nTPM
epididymis: 0.1 nTPM
kidney: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early spermatids: 670 nCPM
late spermatids: 519 nCPM
late primary spermatocytes: 131 nCPM
sertoli cells: 3.6 nCPM
leydig cells: 2.4 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.9 nTPM
cerebral cortex: 0.9 nTPM
hippocampal formation: 0.7 nTPM
amygdala: 0.6 nTPM
pons: 0.6 nTPM
white matter: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Testis-specific expressed protein 55
TEX55, dimerization/docking domain
Testis-specific expressed protein 55

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX55 as an antibody target. Whether an autoantibody or antibody against TEX55 could matter depends on whether native TEX55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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