Seroatlas · Human Serome Atlas

TEX54

Testis-expressed protein 54

Also known as: TEX54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVG6
Gene
TEX54
Ensembl
ENSG00000283268
Chromosome
11
Canonical length
124 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TEX54 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>A0A1B0GVG6|TEX54
     1  MGCCQDKDFE MSDEQSKEEE SEDGREDETT DTQRGPRECE RGLPEGRGEL RGLVVPSGAE
    61  DIDLNSPDHP NHKSNESLLI TVLWRRLSTF GRRGSSRPSK RQPDQIRKQE SPIREGNQEE
   121  PEKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • testis: 74 nTPM
  • salivary gland: 1.7 nTPM
  • pituitary gland: 1.1 nTPM
  • skin: 0.9 nTPM
  • bone marrow: 0.5 nTPM
  • prostate: 0.5 nTPM

Single-cell type

  • early spermatids: 54 nCPM
  • epicardial cells: 18 nCPM
  • adipocytes: 15 nCPM
  • late primary spermatocytes: 11 nCPM
  • cardiomyocytes: 6 nCPM
  • late spermatids: 4.7 nCPM

Immune cell

  • neutrophil: 140 nTPM
  • basophil: 24 nTPM
  • eosinophil: 19 nTPM
  • classical monocyte: 8.4 nTPM
  • naive CD4 T-cell: 8.3 nTPM
  • MAIT T-cell: 7.9 nTPM

Brain region

  • cerebellum: 3.4 nTPM
  • medulla oblongata: 2.3 nTPM
  • cerebral cortex: 2.2 nTPM
  • choroid plexus: 2.2 nTPM
  • midbrain: 2.1 nTPM
  • thalamus: 2 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX54 as an antibody target. Whether an autoantibody or antibody against TEX54 could matter depends on whether native TEX54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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