TEX53
Testis-expressed protein 53
Also known as: TEX53_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GU33
- Gene
- TEX53
- Ensembl
- ENSG00000230054
- Chromosome
- 9
- Canonical length
- 70 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for TEX53 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
70 residues, UniProt reviewed canonical sequence.
>A0A1B0GU33|TEX53
1 MGSKIFCCCR KTSEGSSTTV GFHNPRMFEQ HHPRSFNLNT NSLHSAVPKR HPRLPYDNRM
61 MLKACILRRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- testis: 66 nTPM
- appendix: 0.3 nTPM
- bone marrow: 0.3 nTPM
- skin: 0.3 nTPM
- spleen: 0.2 nTPM
- adipose tissue: 0.1 nTPM
Single-cell type
- late spermatids: 4,475 nCPM
- early spermatids: 799 nCPM
- late primary spermatocytes: 80 nCPM
- adipocytes: 9.7 nCPM
- leydig cells: 6.4 nCPM
- retinal horizontal cells: 6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 8.6 nTPM
- white matter: 8.2 nTPM
- basal ganglia: 5.4 nTPM
- medulla oblongata: 3.5 nTPM
- thalamus: 3.3 nTPM
- midbrain: 3.2 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX53 as an antibody target. Whether an autoantibody or antibody against TEX53 could matter depends on whether native TEX53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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