Seroatlas · Human Serome Atlas

TEX52

Testis-expressed protein 52

Also known as: TEX52_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NCN8
Gene
TEX52
Ensembl
ENSG00000283297
Chromosome
12
Canonical length
305 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for TEX52 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>A6NCN8|TEX52
     1  MASNRQRSLR GPSHPSHMEE PFLQMVQASE SLPPSQTWAQ REFFLPSESW EFPGFTRQAY
    61  HQLALKLPPC TDMKSKVRQR LIHPWKGGAQ HTWGFHTWLD VCRLPATFPT QPDRPYDSNV
   121  WRWLTDSNAH RCPPTEHPIP PPSWMGQNSF LTFIHCYPTF VDMKRKKQVI FRTVKELKEV
   181  EKLKLRSEAR APPLDAQGNI QPPASFKKYR HISAGGRFEP QGLQLMPNPF PNNFARSWPC
   241  PNPLPHYQEK VLKLALLPSA PLSQDLIRDF QTLIKDRTAL PLHHLSKAQA SKSPARKRKR
   301  RPGHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
7.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.9 nTPM
  • skin: 3.3 nTPM
  • retina: 2.6 nTPM
  • skeletal muscle: 2.3 nTPM
  • salivary gland: 1.4 nTPM
  • duodenum: 1.1 nTPM

Single-cell type

  • late spermatids: 269 nCPM
  • early spermatids: 193 nCPM
  • cone photoreceptor cells: 12 nCPM
  • epicardial cells: 11 nCPM
  • late primary spermatocytes: 10 nCPM
  • myonuclei: 8.2 nCPM

Immune cell

  • NK-cell: 1.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 7.3 nTPM
  • white matter: 5 nTPM
  • medulla oblongata: 3.8 nTPM
  • basal ganglia: 3.2 nTPM
  • cerebral cortex: 3.2 nTPM
  • pons: 3.1 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4532
  • Protein of unknown function (DUF4532)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX52 as an antibody target. Whether an autoantibody or antibody against TEX52 could matter depends on whether native TEX52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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