Seroatlas · Human Serome Atlas

TEX51

Testis-expressed protein 51

Also known as: TEX51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUA7
Gene
TEX51
Ensembl
ENSG00000237524
Chromosome
2
Canonical length
166 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>A0A1B0GUA7|TEX51
     1  MLPLLIICLL PAIEGKNCLR CWPELSALID YDLQILWVTP GPPTELSQNR DHLEEETAKF
    61  FTQVHQAIKT LRDDKTVLLE EIYTHKNLFT ERLNKISDGL KEKDIQSTLK VTSCADCRTH
   121  FLSCNDPTFC PARNRRTSLW AVSLSSALLL AIAGDVSFTG KGRRRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • testis: 60 nTPM
  • kidney: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 494 nCPM
  • late primary spermatocytes: 319 nCPM
  • late spermatids: 295 nCPM
  • sertoli cells: 2.3 nCPM
  • leydig cells: 1.5 nCPM
  • early primary spermatocytes: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • choroid plexus: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • pons: 0.1 nTPM
  • amygdala: 0 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX51 as an antibody target. Whether an autoantibody or antibody against TEX51 could matter depends on whether native TEX51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX51. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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