Seroatlas · Human Serome Atlas

TEX50

Testis-expressed protein 50

Also known as: TEX50_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTY4
Gene
TEX50
Ensembl
ENSG00000232113
Chromosome
1
Canonical length
177 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>A0A1B0GTY4|TEX50
     1  MSNQRLPLIF SLLFICFFGE SFCICDGTVW TKVGWEILPE EVHYWKVKGS PSHCLPYLLD
    61  KLCCDFANMD IFQGCLYLIY NLLQAVFFVL FVLSVHYLWK KWKKHQKKLK KQASLEKPGN
   121  DLESPLINNI DQTLHRVATT ASVIYKIWEH RSHHPSSKKI KHCKLKKKSK EEGARRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 260 nCPM
  • late primary spermatocytes: 169 nCPM
  • late spermatids: 60 nCPM
  • sertoli cells: 2.6 nCPM
  • conjunctival goblet cells: 1 nCPM
  • undifferentiated spermatogonia: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 2.5 nTPM
  • medulla oblongata: 1.5 nTPM
  • midbrain: 1.3 nTPM
  • spinal cord: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • hypothalamus: 0.7 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Testis-expressed protein 50

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX50 as an antibody target. Whether an autoantibody or antibody against TEX50 could matter depends on whether native TEX50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX50. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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