TEX47
Testis-expressed protein 47
Also known as: C7orf62, DYBLUF, MGC26647, TEX47_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TBZ9
- Gene
- TEX47
- Ensembl
- ENSG00000164645
- Chromosome
- 7
- Canonical length
- 253 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for TEX47 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
253 residues, UniProt reviewed canonical sequence.
>Q8TBZ9|TEX47
1 MSFSVHNQKG SKRPLPLEPL LFLQVPRSNY LHFQEEKQRL HLKKFLLDRM FLVAKIQANV
61 ERKDVADYYE QMFQSVLKHH LGEAVTGLLL IYPTSILHIL ESSSDTLYKV LLDYIGHVKD
121 ETVFFIQQMK IIVISHNIPM RLFMQWHVSV IKVPVMYLDD VTQSQSLKEV ITDFLTQTHK
181 LSLYLCQTMK VGTKGPGDNL HQVAPDLLLP EQIIKYLCKS EEFMDPATFI NMYNRPIHIT
241 LDSEVVWPAP SRFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- testis: 27 nTPM
- retina: 0.1 nTPM
- thyroid gland: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- late primary spermatocytes: 177 nCPM
- early spermatids: 163 nCPM
- late spermatids: 106 nCPM
- retinal bipolar cells: 2.9 nCPM
- peritubular myoid cells: 0.7 nCPM
- hematopoietic stem cells: 0.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 13 nTPM
- white matter: 5.9 nTPM
- hypothalamus: 5.1 nTPM
- pons: 4.1 nTPM
- basal ganglia: 4 nTPM
- thalamus: 3.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Testis-expressed protein 47-like
- Testis-expressed protein 47
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX47 as an antibody target. Whether an autoantibody or antibody against TEX47 could matter depends on whether native TEX47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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