Seroatlas · Human Serome Atlas

TEX46

Testis-expressed protein 46

Also known as: C1orf234, TEX46_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BTG2
Gene
TEX46
Ensembl
ENSG00000227868
Chromosome
1
Canonical length
121 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in single fertilization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>H3BTG2|TEX46
     1  MSLHGILASA GTIGAVAAWL MSYKPALFGF LFLLLLLSNW LVKYEHKLTL PEPQQDEILQ
    61  RLLFSEMKMK VLENQMFIIW NKMNHHGRSS RHRNFPMKKH RMRRHESICP TLSDCTSSSP
   121  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • testis: 59 nTPM
  • epididymis: 0.7 nTPM
  • skin: 0.6 nTPM
  • choroid plexus: 0.5 nTPM
  • retina: 0.5 nTPM
  • pancreas: 0.4 nTPM

Single-cell type

  • late spermatids: 3,551 nCPM
  • early spermatids: 819 nCPM
  • late primary spermatocytes: 168 nCPM
  • undifferentiated spermatogonia: 14 nCPM
  • sertoli cells: 7.8 nCPM
  • leydig cells: 6.3 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 2.8 nTPM
  • hypothalamus: 2.7 nTPM
  • cerebral cortex: 2.3 nTPM
  • thalamus: 2.3 nTPM
  • basal ganglia: 2.1 nTPM
  • medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.01
DepMap mean gene effect
-0.16
DepMap dependency class
selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Testis-expressed protein 46-like
  • Family of unknown function (DUF5531)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX46 as an antibody target. Whether an autoantibody or antibody against TEX46 could matter depends on whether native TEX46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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