Seroatlas · Human Serome Atlas

TEX44

Testis-expressed protein 44

Also known as: C2orf57, MGC35154, TEX44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53QW1
Gene: TEX44
Ensembl: ENSG00000177673
Chromosome: 2
Canonical length: 395 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q53QW1|TEX44
     1  MALPGYPLGN VDDSRSKDSP AGEPQGQVPL TADVLAVSSS VASTDWQDID QASFKTATPR
    61  AISTSGDKDK SAVVPEHGQK TPRKITPLLP SQNPSPLQVS MSLQNPAWDR QVQDARTSQS
   121  LVVFPSHLLG KDKMSQMASV PEREPESAPS APSAELQSTQ HMEAQPVESD ADHVTAGANG
   181  QHGPQAASTT KSAEEKAEHP KAPHPEAEAL PSDESPVAMG ANVVDSLGDL QTWFFPPPPA
   241  GSVSPSPGPH EVALGRRPLD SSLYTASEEN SYMRSMTSLL DRGEGSISSL ADILVWSETT
   301  MGMAIATGFL DSGHSTVADL LHSSGPSLRS VPSLVGSVSS AFSSGLVSGT SSALRTITRV
   361  LETVEQRTVE GIRSAMRYLT SHLTPRQAQA DPNYD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 147 nTPM

Expression across tissuesHPA

Tissue

testis: 147 nTPM
breast: 0.1 nTPM
fallopian tube: 0.1 nTPM
prostate: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 5,983 nCPM
early spermatids: 1000 nCPM
late primary spermatocytes: 75 nCPM
sertoli cells: 8.7 nCPM
leydig cells: 7.8 nCPM
undifferentiated spermatogonia: 4.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM
spinal cord: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4678
Domain of unknown function (DUF4678)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX44 as an antibody target. Whether an autoantibody or antibody against TEX44 could matter depends on whether native TEX44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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