Seroatlas · Human Serome Atlas

TEX36

Testis-expressed protein 36

Also known as: bA383C5.1, C10orf122, TEX36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VZQ5
Gene
TEX36
Ensembl
ENSG00000175018
Chromosome
10
Canonical length
186 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for TEX36 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q5VZQ5|TEX36
     1  MTKGRRFNPP SDKDGRWFPH IGLTQKTPES ITSATSKEPQ SPHLPRQAEG KLPPIYKVRE
    61  KQAVNNQFPF SVHDNRHSLE NSGCYLDSGL GRKKISPDKR QHVSRNFNLW ACDYVPSCLD
   121  GFSNNQISYV YKEAMVVSSF RRFPRCYKEI WNAFTFLPER SYTEVLKKKP KVRFTVDKKV
   181  VSSLES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • testis: 25 nTPM
  • smooth muscle: 0.4 nTPM
  • endometrium: 0.3 nTPM
  • skin: 0.3 nTPM
  • cervix: 0.2 nTPM
  • esophagus: 0.2 nTPM

Single-cell type

  • late spermatids: 631 nCPM
  • early spermatids: 429 nCPM
  • late primary spermatocytes: 175 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • epicardial cells: 2.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX36 as an antibody target. Whether an autoantibody or antibody against TEX36 could matter depends on whether native TEX36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...