Seroatlas · Human Serome Atlas

TEX35

Testis-expressed protein 35

Also known as: C1orf49, DKFZP564J047, TEX35_HUMAN, TSC24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T0J7
Gene
TEX35
Ensembl
ENSG00000240021
Chromosome
1
Canonical length
233 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q5T0J7|TEX35
     1  MSAKRAELKK THLSKNYKAV CLELKPEPTK TFDYKAVKQE GRFTKAGVTQ DLKNELREVR
    61  EELKEKMEEI KQIKDLMDKD FDKLHEFVEI MKEMQKDMDE KMDILINTQK NYKLPLRRAP
   121  KEQQELRLMG KTHREPQLRP KKMDGASGVN GAPCALHKKT MAPQKTKQGS LDPLHHCGTC
   181  CEKCLLCALK NNYNRGNIPS EASGLYKGGE EPVTTQPSVG HAVPAPKSQT EGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • testis: 112 nTPM
  • bone marrow: 1.8 nTPM
  • retina: 1.4 nTPM
  • skin: 1.4 nTPM
  • stomach: 1.4 nTPM
  • duodenum: 1.3 nTPM

Single-cell type

  • late spermatids: 3,259 nCPM
  • early spermatids: 1,551 nCPM
  • late primary spermatocytes: 281 nCPM
  • foveolar cells: 12 nCPM
  • epididymal principal cells: 12 nCPM
  • sertoli cells: 9.2 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 38 nTPM
  • white matter: 29 nTPM
  • cerebral cortex: 28 nTPM
  • basal ganglia: 27 nTPM
  • hypothalamus: 25 nTPM
  • pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Testis-expressed sequence 35 protein
  • Testis-specific protein 35

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX35 as an antibody target. Whether an autoantibody or antibody against TEX35 could matter depends on whether native TEX35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX35. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...