TEX30
Testis-expressed protein 30
Also known as: C13orf27, TEX30_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JUR7
- Gene
- TEX30
- Ensembl
- ENSG00000151287
- Chromosome
- 13
- Canonical length
- 227 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for TEX30 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
227 residues, UniProt reviewed canonical sequence.
>Q5JUR7|TEX30
1 MSHTEVKLKI PFGNKLLDAV CLVPNKSLTY GIILTHGASG DMNLPHLMSL ASHLASHGFF
61 CLRFTCKGLN IVHRIKAYKS VLNYLKTSGE YKLAGVFLGG RSMGSRAAAS VMCHIEPDDG
121 DDFVRGLICI SYPLHHPKQQ HKLRDEDLFR LKEPVLFVSG SADEMCEKNL LEKVAQKMQA
181 PHKIHWIEKA NHSMAVKGRS TNDVFKEINT QILFWIQEIT EMDKKCHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- testis: 115 nTPM
- epididymis: 67 nTPM
- liver: 37 nTPM
- kidney: 18 nTPM
- thymus: 15 nTPM
- placenta: 14 nTPM
Single-cell type
- late primary spermatocytes: 979 nCPM
- early primary spermatocytes: 929 nCPM
- oocytes: 438 nCPM
- early spermatids: 348 nCPM
- epididymal principal cells: 194 nCPM
- differentiating spermatogonia: 177 nCPM
Immune cell
- basophil: 366 nTPM
- eosinophil: 80 nTPM
- NK-cell: 29 nTPM
- T-reg: 19 nTPM
- plasmacytoid DC: 18 nTPM
- MAIT T-cell: 15 nTPM
Brain region
- cerebral cortex: 8 nTPM
- thalamus: 7.9 nTPM
- cerebellum: 6.9 nTPM
- amygdala: 6.5 nTPM
- white matter: 6.5 nTPM
- midbrain: 6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX30 as an antibody target. Whether an autoantibody or antibody against TEX30 could matter depends on whether native TEX30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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