Seroatlas · Human Serome Atlas

TEX29

Testis-expressed protein 29

Also known as: bA474D23.1, C13orf16, MGC35169, TEX29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6K0
Gene
TEX29
Ensembl
ENSG00000153495
Chromosome
13
Canonical length
151 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>Q8N6K0|TEX29
     1  MEYVLEVKNS PRHLLKQFTV CDVPLYDICD YNVSRDRCQE LGCCFYEGVC YKKAVPIYIH
    61  VFSALIVIIA GAFVITIIYR VIQESRKEKA IPVDVALPQK SSEKAELASS SSKLGLKPAS
   121  PGPPSAGPSM KSDEDKDDVT GTITEAEETE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • testis: 49 nTPM
  • cerebral cortex: 12 nTPM
  • amygdala: 5.4 nTPM
  • basal ganglia: 3.6 nTPM
  • hippocampal formation: 1.8 nTPM
  • pituitary gland: 1.3 nTPM

Single-cell type

  • early spermatids: 1,108 nCPM
  • late spermatids: 266 nCPM
  • late primary spermatocytes: 188 nCPM
  • thymocytes: 14 nCPM
  • oocytes: 14 nCPM
  • vascular smooth muscle cells: 11 nCPM

Immune cell

  • eosinophil: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 5.2 nTPM
  • white matter: 3.3 nTPM
  • cerebellum: 2.8 nTPM
  • amygdala: 2.6 nTPM
  • basal ganglia: 2.4 nTPM
  • hippocampal formation: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Testis-expressed sequence 29 protein
  • Testis-expressed sequence 29 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX29 as an antibody target. Whether an autoantibody or antibody against TEX29 could matter depends on whether native TEX29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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