TEX261
Protein TEX261
Also known as: MGC32043, TEG-261, TX261_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWH6
- Gene
- TEX261
- Ensembl
- ENSG00000144043
- Chromosome
- 2
- Canonical length
- 196 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable COPII receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
196 residues, UniProt reviewed canonical sequence.
>Q6UWH6|TEX261
1 MWFMYLLSWL SLFIQVAFIT LAVAAGLYYL AELIEEYTVA TSRIIKYMIW FSTAVLIGLY
61 VFERFPTSMI GVGLFTNLVY FGLLQTFPFI MLTSPNFILS CGLVVVNHYL AFQFFAEEYY
121 PFSEVLAYFT FCLWIIPFAF FVSLSAGENV LPSTMQPGDD VVSNYFTKGK RGKRLGILVV
181 FSFIKEAILP SRQKIYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX261 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 62 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 62 nTPM
- skeletal muscle: 55 nTPM
- tongue: 51 nTPM
- pancreas: 47 nTPM
- thyroid gland: 43 nTPM
- epididymis: 43 nTPM
Single-cell type
- tuft cells: 12 nCPM
- gastric progenitor cells: 2.6 nCPM
- parietal cells: 1.8 nCPM
- breast myoepithelial cells: 1.7 nCPM
- late primary spermatocytes: 1.7 nCPM
- late spermatids: 1.6 nCPM
Immune cell
- basophil: 8.8 nTPM
- eosinophil: 7.7 nTPM
- memory CD8 T-cell: 4.6 nTPM
- naive CD4 T-cell: 4.2 nTPM
- intermediate monocyte: 3.9 nTPM
- non-classical monocyte: 3.9 nTPM
Brain region
- choroid plexus: 42 nTPM
- medulla oblongata: 41 nTPM
- basal ganglia: 32 nTPM
- midbrain: 32 nTPM
- thalamus: 30 nTPM
- white matter: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.13
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.24
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Svp26/Tex261
- Transmembrane adaptor Erv26
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX261 as an antibody target. Whether an autoantibody or antibody against TEX261 could matter depends on whether native TEX261 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX261 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX261 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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