Seroatlas · Human Serome Atlas

TEX26

Testis-expressed protein 26

Also known as: C13orf26, MGC40178, TEX26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6G2
Gene: TEX26
Ensembl: ENSG00000175664
Chromosome: 13
Canonical length: 289 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q8N6G2|TEX26
     1  MEQPGPRAPD PSLCHHNLQP TDDPNWDSYA TTMRTAFTPK TGAVPALIRQ NGIRRLGYTY
    61  SLSDPILNQT QYSDEYTWKS HSKEDLIKTE TSRGIKSHKS HLNEDIFLWT LPHCQQTGTL
   121  KNCLPWKIPA SMKEVNKALS NQFISLTKRD FVDRSKAQKI KKSSHLSLEW KKLLPQPPDT
   181  EFRRNYQIPA KIPELQDFSF KYGCYSSLPV ASQGLVPSVL HSYLRNQEHT KKQTTYQSDY
   241  DKTYPDFLML LNSFTSSQVK EYLQSLSYKD RQIIDRFIRT HCDTNKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
choroid plexus: 11 nTPM
hypothalamus: 3.4 nTPM
basal ganglia: 1.3 nTPM
hippocampal formation: 1.2 nTPM
pituitary gland: 1.2 nTPM

Single-cell type

late spermatids: 2,861 nCPM
early spermatids: 1,081 nCPM
late primary spermatocytes: 236 nCPM
ependymal cells: 92 nCPM
respiratory ciliated cells: 80 nCPM
choroid plexus epithelial cells: 73 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 8.9 nTPM
hypothalamus: 8.8 nTPM
medulla oblongata: 4.2 nTPM
midbrain: 4 nTPM
spinal cord: 3.4 nTPM
pons: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -1.13
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

MEDAG/TEX26

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX26 as an antibody target. Whether an autoantibody or antibody against TEX26 could matter depends on whether native TEX26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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