Seroatlas · Human Serome Atlas

TEX22

Testis-expressed protein 22

Also known as: TEX22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J3V5
Gene
TEX22
Ensembl
ENSG00000226174
Chromosome
14
Canonical length
150 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>C9J3V5|TEX22
     1  MDSRKLSPRG KKLESHLSQE HRRPPLGLIA AWGQPSIQSS VQQGLQTQDW VCEPPERRRP
    61  GRRWSVSIDE RRRLATLGGR ERPGAAGTQL HCRDVVQMVA QLVSEDVDKD VLLPHPLRST
   121  ESTNAFQAFL ARSAPFWHNA TFEASRSPPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.5 nTPM
  • thymus: 0.9 nTPM
  • kidney: 0.6 nTPM
  • ovary: 0.6 nTPM
  • spleen: 0.6 nTPM
  • amygdala: 0.5 nTPM

Single-cell type

  • late spermatids: 971 nCPM
  • early spermatids: 305 nCPM
  • late primary spermatocytes: 245 nCPM
  • ependymal cells: 28 nCPM
  • thymocytes: 24 nCPM
  • bergmann glia: 24 nCPM

Immune cell

  • classical monocyte: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 2.7 nTPM
  • cerebellum: 2.6 nTPM
  • medulla oblongata: 2.3 nTPM
  • midbrain: 2.1 nTPM
  • basal ganglia: 2 nTPM
  • pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.02
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX22 as an antibody target. Whether an autoantibody or antibody against TEX22 could matter depends on whether native TEX22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEX22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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