Seroatlas · Human Serome Atlas

TEX13B

Testis-expressed protein 13B

Also known as: TGC3B, TSGA5, TX13B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXU2
Gene: TEX13B
Ensembl: ENSG00000170925
Chromosome: X
Canonical length: 312 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is similar to a mouse gene that is expressed in the testis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q9BXU2|TEX13B
     1  MALRPEDPSS GFRHGNVVAF IIEKMARHTK GPEFYFENIS LSWEEVEDKL RAILEDSEVP
    61  SEVKEACTWG SLALGVRFAH RQGQLQNRRV QWLQGFAKLH RSAALVLASN LTELKEQQEM
   121  ECNEATFQLQ LTETSLAEVQ RERDMLRWKL FHAELAPPQG QGQATVFPGL ATAGGDWTEG
   181  AGEQEKEAVA AAGAAGGKGE ERYAEAGPAP AEVLQGLGGG FRQPLGAIVA GKLHLCGAEG
   241  ERSQVSTNSH VCLLWAWVHS LTGASSCPAP YLIHILIPMP FVRLLSHTQY TPFTSKGHRT
   301  GSNSDAFQLG GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 0.6 nCPM
undifferentiated spermatogonia: 0.4 nCPM
late primary spermatocytes: 0.3 nCPM
retinal bipolar cells: 0.2 nCPM
early primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.9 nTPM
cerebral cortex: 1.4 nTPM
hypothalamus: 1.4 nTPM
amygdala: 1 nTPM
midbrain: 0.9 nTPM
thalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0.01
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mRNA binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX13B as an antibody target. Whether an autoantibody or antibody against TEX13B could matter depends on whether native TEX13B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX13B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX13B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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