Seroatlas · Human Serome Atlas

TESMIN

Tesmin

Also known as: CXCDC2, MTL5, MTL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4I5
Gene: TESMIN
Ensembl: ENSG00000132749
Chromosome: 11
Canonical length: 508 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q9Y4I5|TESMIN
     1  MEEGPLPGGL PSPEDAMVTE LLSPEGPFAS ENIGLKAPVK YEEDEFHVFK EAYLGPADPK
    61  EPVLHAFNPA LGADCKGQVK AKLAGGDSDG GELLGEYPGI PELSALEDVA LLQAPQPPAC
   121  NVHFLSSLLP AHRSPAVLPL GAWVLEGASH PGVRMIPVEI KEAGGTTTSN NPEEATLQNL
   181  LAQESCCKFP SSQELEDASC CSLKKDSNPM VICQLKGGTQ MLCIDNSRTR ELKALHLVPQ
   241  YQDQNNYLQS DVPKPMTALV GRFLPASTKL NLITQQLEGA LPSVVNGSAF PSGSTLPGPP
   301  KITLAGYCDC FASGDFCNNC NCNNCCNNLH HDIERFKAIK ACLGRNPEAF QPKIGKGQLG
   361  NVKPQHNKGC NCRRSGCLKN YCECYEAQIM CSSICKCIGC KNYEESPERK TLMSMPNYMQ
   421  TGGLEGSHYL PPTKFSGLPR FSHDRRPSSC ISWEVVEATC ACLLAQGEEA EKEHCSKCLA
   481  EQMILEEFGR CLSQILHTEF KSKGLKME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TESMIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

testis: 49 nTPM
bone marrow: 7 nTPM
breast: 4 nTPM
kidney: 3.2 nTPM
rectum: 2.8 nTPM
colon: 2.4 nTPM

Single-cell type

late primary spermatocytes: 247 nCPM
late spermatids: 215 nCPM
early primary spermatocytes: 132 nCPM
early spermatids: 106 nCPM
oocytes: 78 nCPM
endometrial luminal cells: 48 nCPM

Immune cell

neutrophil: 0.5 nTPM
classical monocyte: 0.2 nTPM
eosinophil: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

pons: 4.1 nTPM
hypothalamus: 3.3 nTPM
medulla oblongata: 3.3 nTPM
basal ganglia: 3 nTPM
midbrain: 3 nTPM
cerebellum: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TESMIN as an antibody target. Whether an autoantibody or antibody against TESMIN could matter depends on whether native TESMIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TESMIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TESMIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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