Seroatlas · Human Serome Atlas

TERB2

Telomere repeats-binding bouquet formation protein 2

Also known as: C15orf43, MGC33951, TERB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHR7
Gene
TERB2
Ensembl
ENSG00000167014
Chromosome
15
Canonical length
220 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within meiosis I; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. Implicated in spermatogenic failure 59. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q8NHR7|TERB2
     1  MFQGQRGWFC GSVSQDLRQF WVAEGGTISD PRAADFLFSC DASHPDTLRI YQSLDYIEDN
    61  ATVFHAYYLS AVANAKIKNS VALGHFILPP ACLQKEIRRK IGSFIWEQDQ HFLIEKHDEV
   121  TPNEIKTLRE NSELATEHKK ELSKSPEKHF IRTPVVEKQM YFPLQNYPVN NMVTGYISID
   181  AMKKFLGELH DFIPGTSGYL AYHVQNEINM SAIKNKLKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TERB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • liver: 1.8 nTPM
  • breast: 1.1 nTPM
  • cervix: 0.7 nTPM
  • seminal vesicle: 0.4 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • late primary spermatocytes: 244 nCPM
  • early primary spermatocytes: 119 nCPM
  • gastric progenitor cells: 22 nCPM
  • early spermatids: 14 nCPM
  • late spermatids: 12 nCPM
  • hepatocytes: 9.5 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TERB2.

Disease | AllUniProt

Conditions TERB2 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 10 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Telomere repeats-binding bouquet formation protein 2
  • Telomere-associated protein TERB2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TERB2 as an antibody target. Whether an autoantibody or antibody against TERB2 could matter depends on whether native TERB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TERB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TERB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TERB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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