Seroatlas · Human Serome Atlas

TEPSIN

AP-4 complex accessory subunit Tepsin

Also known as: AP4AT_HUMAN, C17orf56, ENTHD2, FLJ31528

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N21
Gene: TEPSIN
Ensembl: ENSG00000167302
Chromosome: 17
Canonical length: 525 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Located in coated vesicle membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q96N21|TEPSIN
     1  MAAAPPLRDR LSFLHRLPIL LKGTSDDDVP CPGYLFEEIA KISHESPGSS QCLLEYLLSR
    61  LHSSSGHGKL KVLKILLYLC SHGSSFFLLI LKRNSAFIQE AAAFAGPPDP LHGNSLYQKV
   121  RAAAQDLGST LFSDTVLPLA PSQPLGTPPA TGMGSQARPH STLQGFGYSK EHGRTAVRHQ
   181  PGQAGGGWDE LDSGPSSQNS SQNSDLSRVS DSGSHSGSDS HSGASREPGD LAERVEVVAL
   241  SDCQQELSLV RTVTRGPRAF LSREEAQHFI KACGLLNCEA VLQLLTCHLR GTSECTQLRA
   301  LCAIASLGSS DLLPQEHILL RTRPWLQELS MGSPGPVTNK ATKILRHFEA SCGQLSPARG
   361  TSAEPGPTAA LPGPSDLLTD AVPLPGSQVF LQPLSSTPVS SRSPAPSSGM PSSPVPTPPP
   421  DASPIPAPGD PSEAEARLAE SRRWRPERIP GGTDSPKRGP SSCAWSRDSL FAGMELVACP
   481  RLVGAGAAAG ESCPDAPRAP QTSSQRTAAK EPPGSEPSAF AFLNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEPSIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

spleen: 33 nTPM
small intestine: 22 nTPM
liver: 20 nTPM
thyroid gland: 19 nTPM
kidney: 18 nTPM
prostate: 18 nTPM

Single-cell type

tuft cells: 46 nCPM
microglia: 19 nCPM
neutrophils: 16 nCPM
late primary spermatocytes: 15 nCPM
differentiating spermatogonia: 14 nCPM
early primary spermatocytes: 13 nCPM

Immune cell

eosinophil: 4 nTPM
basophil: 2.4 nTPM
neutrophil: 2.1 nTPM
naive B-cell: 1.8 nTPM
intermediate monocyte: 1.6 nTPM
plasmacytoid DC: 1.4 nTPM

Brain region

medulla oblongata: 8.7 nTPM
choroid plexus: 8.3 nTPM
thalamus: 8.2 nTPM
cerebral cortex: 7.8 nTPM
pons: 7.8 nTPM
white matter: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

ENTH/VHS
ENTH domain
ENTH domain
Tepsin, ENTH/VHS domain
AP-4 complex accessory subunit Tepsin
AP-4 complex accessory subunit Tepsin, VHS/ENTH-like domain
Tepsin VHS/ENTH-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEPSIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEPSIN as an antibody target. Whether an autoantibody or antibody against TEPSIN could matter depends on whether native TEPSIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEPSIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEPSIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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