Seroatlas · Human Serome Atlas

TENT5D

Terminal nucleotidyltransferase 5D

Also known as: CT1.26, CT112, FAM46D, MGC26999, TET5D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEK8
Gene: TENT5D
Ensembl: ENSG00000174016
Chromosome: X
Canonical length: 389 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q8NEK8|TENT5D
     1  MSEIRFTNLT WDQVITLDQV LDEVIPIHGK GNFPTMEVKP KDIIHVVKDQ LIGQGIIVKD
    61  ARLNGSVASY ILASHNGISY KDLDVIFGVE LPGNEEFQVV KDAVLDCLLD FLPKDVKKEK
   121  LSPDIMKDAY VQKLVKVCNG HDCWSLISLS NNTGKNLELK FVSSLRRQFE FSVDSFQIVL
   181  DPMLDFYSDK NAKLTKESYP VVVAESMYGD FQEAMTHLQH KLICTRKPEE IRGGGLLKYC
   241  SLLVHGFKPA CMSEIKNLER YMCSRFFIDF PHIEEQQKKI ESYLHNHFIG EGMTKYDYLM
   301  TLHGVVNEST VCLMSYERRQ ILHLITMMAL KVLGELNILP NTQKVTCFYQ PAPYFAAEAR
   361  YPIYVIPEPP PVSFQPYHPL HFRGSNGMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT5D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

testis: 3.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 30 nCPM
early spermatids: 18 nCPM
undifferentiated spermatogonia: 15 nCPM
differentiating spermatogonia: 11 nCPM
early primary spermatocytes: 7.9 nCPM
sertoli cells: 7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.83
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA stabilization

Molecular functions

poly(A) RNA polymerase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENT5D as an antibody target. Whether an autoantibody or antibody against TENT5D could matter depends on whether native TENT5D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENT5D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Antibodies against the protein encoded by this gene were found only in plasma from cancer patients.

Loading the interactive Seroatlas protein explorer...