Seroatlas · Human Serome Atlas

TENM3

Teneurin-3

Also known as: KIAA1455, ODZ3, Ten-M3, TEN3, TEN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P273
Gene
TENM3
Ensembl
ENSG00000218336
Chromosome
4
Canonical length
2699 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cell Junctions,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the teneurin transmembrane protein family. The encoded protein may be involved in the regulation of neuronal development including development of the visual pathway. Mutations in this gene have been associated with microphthalmia and developmental dysplasia of the hip. [provided by RefSeq, Jan 2023]

Canonical amino-acid sequenceUniProt

2699 residues, UniProt reviewed canonical sequence.

>Q9P273|TENM3
     1  MDVKERRPYC SLTKSRREKE RRYTNSSADN EECRVPTQKS YSSSETLKAF DHDSSRLLYG
    61  NRVKDLVHRE ADEFTRQGQN FTLRQLGVCE PATRRGLAFC AEMGLPHRGY SISAGSDADT
   121  ENEAVMSPEH AMRLWGRGVK SGRSSCLSSR SNSALTLTDT EHENKSDSEN EQPASNQGQS
   181  TLQPLPPSHK QHSAQHHPSI TSLNRNSLTN RRNQSPAPPA ALPAELQTTP ESVQLQDSWV
   241  LGSNVPLESR HFLFKTGTGT TPLFSTATPG YTMASGSVYS PPTRPLPRNT LSRSAFKFKK
   301  SSKYCSWKCT ALCAVGVSVL LAILLSYFIA MHLFGLNWQL QQTENDTFEN GKVNSDTMPT
   361  NTVSLPSGDN GKLGGFTQEN NTIDSGELDI GRRAIQEIPP GIFWRSQLFI DQPQFLKFNI
   421  SLQKDALIGV YGRKGLPPSH TQYDFVELLD GSRLIAREQR SLLETERAGR QARSVSLHEA
   481  GFIQYLDSGI WHLAFYNDGK NAEQVSFNTI VIESVVECPR NCHGNGECVS GTCHCFPGFL
   541  GPDCSRAACP VLCSGNGQYS KGRCLCFSGW KGTECDVPTT QCIDPQCGGR GICIMGSCAC
   601  NSGYKGESCE EADCIDPGCS NHGVCIHGEC HCSPGWGGSN CEILKTMCPD QCSGHGTYLQ
   661  ESGSCTCDPN WTGPDCSNEI CSVDCGSHGV CMGGTCRCEE GWTGPACNQR ACHPRCAEHG
   721  TCKDGKCECS QGWNGEHCTI EGCPGLCNSN GRCTLDQNGW HCVCQPGWRG AGCDVAMETL
   781  CTDSKDNEGD GLIDCMDPDC CLQSSCQNQP YCRGLPDPQD IISQSLQSPS QQAAKSFYDR
   841  ISFLIGSDST HVIPGESPFN KSLASVIRGQ VLTADGTPLI GVNVSFFHYP EYGYTITRQD
   901  GMFDLVANGG ASLTLVFERS PFLTQYHTVW IPWNVFYVMD TLVMKKEEND IPSCDLSGFV
   961  RPNPIIVSSP LSTFFRSSPE DSPIIPETQV LHEETTIPGT DLKLSYLSSR AAGYKSVLKI
  1021  TMTQSIIPFN LMKVHLMVAV VGRLFQKWFP ASPNLAYTFI WDKTDAYNQK VYGLSEAVVS
  1081  VGYEYESCLD LTLWEKRTAI LQGYELDASN MGGWTLDKHH VLDVQNGILY KGNGENQFIS
  1141  QQPPVVSSIM GNGRRRSISC PSCNGQADGN KLLAPVALAC GIDGSLYVGD FNYVRRIFPS
  1201  GNVTSVLELS SNPAHRYYLA TDPVTGDLYV SDTNTRRIYR PKSLTGAKDL TKNAEVVAGT
  1261  GEQCLPFDEA RCGDGGKAVE ATLMSPKGMA VDKNGLIYFV DGTMIRKVDQ NGIISTLLGS
  1321  NDLTSARPLT CDTSMHISQV RLEWPTDLAI NPMDNSIYVL DNNVVLQITE NRQVRIAAGR
  1381  PMHCQVPGVE YPVGKHAVQT TLESATAIAV SYSGVLYITE TDEKKINRIR QVTTDGEISL
  1441  VAGIPSECDC KNDANCDCYQ SGDGYAKDAK LSAPSSLAAS PDGTLYIADL GNIRIRAVSK
  1501  NKPLLNSMNF YEVASPTDQE LYIFDINGTH QYTVSLVTGD YLYNFSYSND NDITAVTDSN
  1561  GNTLRIRRDP NRMPVRVVSP DNQVIWLTIG TNGCLKSMTA QGLELVLFTY HGNSGLLATK
  1621  SDETGWTTFF DYDSEGRLTN VTFPTGVVTN LHGDMDKAIT VDIESSSREE DVSITSNLSS
  1681  IDSFYTMVQD QLRNSYQIGY DGSLRIIYAS GLDSHYQTEP HVLAGTANPT VAKRNMTLPG
  1741  ENGQNLVEWR FRKEQAQGKV NVFGRKLRVN GRNLLSVDFD RTTKTEKIYD DHRKFLLRIA
  1801  YDTSGHPTLW LPSSKLMAVN VTYSSTGQIA SIQRGTTSEK VDYDGQGRIV SRVFADGKTW
  1861  SYTYLEKSMV LLLHSQRQYI FEYDMWDRLS AITMPSVARH TMQTIRSIGY YRNIYNPPES
  1921  NASIITDYNE EGLLLQTAFL GTSRRVLFKY RRQTRLSEIL YDSTRVSFTY DETAGVLKTV
  1981  NLQSDGFICT IRYRQIGPLI DRQIFRFSED GMVNARFDYS YDNSFRVTSM QGVINETPLP
  2041  IDLYQFDDIS GKVEQFGKFG VIYYDINQII STAVMTYTKH FDAHGRIKEI QYEIFRSLMY
  2101  WITIQYDNMG RVTKREIKIG PFANTTKYAY EYDVDGQLQT VYLNEKIMWR YNYDLNGNLH
  2161  LLNPSNSARL TPLRYDLRDR ITRLGDVQYR LDEDGFLRQR GTEIFEYSSK GLLTRVYSKG
  2221  SGWTVIYRYD GLGRRVSSKT SLGQHLQFFY ADLTYPTRIT HVYNHSSSEI TSLYYDLQGH
  2281  LFAMEISSGD EFYIASDNTG TPLAVFSSNG LMLKQIQYTA YGEIYFDSNI DFQLVIGFHG
  2341  GLYDPLTKLI HFGERDYDIL AGRWTTPDIE IWKRIGKDPA PFNLYMFRNN NPASKIHDVK
  2401  DYITDVNSWL VTFGFHLHNA IPGFPVPKFD LTEPSYELVK SQQWDDIPPI FGVQQQVARQ
  2461  AKAFLSLGKM AEVQVSRRRA GGAQSWLWFA TVKSLIGKGV MLAVSQGRVQ TNVLNIANED
  2521  CIKVAAVLNN AFYLENLHFT IEGKDTHYFI KTTTPESDLG TLRLTSGRKA LENGINVTVS
  2581  QSTTVVNGRT RRFADVEMQF GALALHVRYG MTLDEEKARI LEQARQRALA RAWAREQQRV
  2641  RDGEEGARLW TEGEKRQLLS AGKVQGYDGY YVLSVEQYPE LADSANNIQF LRQSEIGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 12 nTPM
  • cerebral cortex: 6.8 nTPM
  • thyroid gland: 5.7 nTPM
  • adrenal gland: 4.8 nTPM
  • parathyroid gland: 4.8 nTPM
  • adipose tissue: 4.7 nTPM

Single-cell type

  • cytotrophoblasts: 2,024 nCPM
  • syncytiotrophoblasts: 1,527 nCPM
  • adrenal cortex cells: 1,331 nCPM
  • migrating cytotrophoblasts: 1,234 nCPM
  • pituitary stem cells: 1,230 nCPM
  • pituicytes/fscs: 1,090 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 113 nTPM
  • basal ganglia: 106 nTPM
  • hypothalamus: 87 nTPM
  • thalamus: 79 nTPM
  • amygdala: 76 nTPM
  • midbrain: 76 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TENM3.

Disease | AllUniProt

Conditions TENM3 is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 668 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microphthalmia, isolated, with coloboma 9
  • MICROPHTHALMIA, SYNDROMIC 15

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
1
gnomAD missense Z
3.3
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENM3 as an antibody target. Whether an autoantibody or antibody against TENM3 could matter depends on whether native TENM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENM3 is annotated at the cell surface, where native TENM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TENM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TENM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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