Seroatlas · Human Serome Atlas

TEN1

CST complex subunit TEN1

Also known as: C17orf106, FLJ39785, TEN1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WV5
Gene: TEN1
Ensembl: ENSG00000257949
Chromosome: 17
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q86WV5|TEN1
     1  MMLPKPGTYY LPWEVSAGQV PDGSTLRTFG RLCLYDMIQS RVTLMAQHGS DQHQVLVCTK
    61  LVEPFHAQVG SLYIVLGELQ HQQDRGSVVK ARVLTCVEGM NLPLLEQAIR EQRLYKQERG
   121  GSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

liver: 49 nTPM
skin: 45 nTPM
esophagus: 43 nTPM
pancreas: 32 nTPM
bone marrow: 31 nTPM
kidney: 28 nTPM

Single-cell type

proximal tubule cells: 12 nCPM
papillary tip epithelial cells: 7.7 nCPM
renal collecting duct intercalated cells: 6.9 nCPM
loop of henle epithelial cells: 6.7 nCPM
renal connecting tubule cells: 6.4 nCPM
choroid plexus epithelial cells: 5.8 nCPM

Immune cell

basophil: 82 nTPM
memory B-cell: 61 nTPM
classical monocyte: 54 nTPM
plasmacytoid DC: 53 nTPM
intermediate monocyte: 53 nTPM
naive B-cell: 49 nTPM

Brain region

choroid plexus: 13 nTPM
pons: 13 nTPM
cerebral cortex: 13 nTPM
midbrain: 12 nTPM
white matter: 12 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.02
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleic acid-binding, OB-fold
CST complex subunit Ten1, animal and plant type
Telomere-capping, CST complex subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEN1 as an antibody target. Whether an autoantibody or antibody against TEN1 could matter depends on whether native TEN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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