Seroatlas · Human Serome Atlas

TEKTL1

Tektin-like protein 1

Also known as: CCDC105, FLJ40365, TEKL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYK2
Gene: TEKTL1
Ensembl: ENSG00000160994
Chromosome: 19
Canonical length: 499 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q8IYK2|TEKTL1
     1  MRVLVPPAER SQDTRVGAPA WREAAQAMAR TAHILTDRCG QEAVTMWQPK DSVLDPNVAH
    61  HLGRAAYIQP WRFRVEMIKG GGTLEKPPPG EGVTLWKGKM KPPAWYARLP LPLHRKARAL
   121  QTTEVVHAHA RGARLTAARL GRAQHQINGR VRQLLRQREV TDHRLSEVRK GLLINQQSVK
   181  LRGYRPKSEK VPDKADSMLT WEKEELKSMK RKMERDMEKS EVLLKTLASC RDTLNFCFKE
   241  RLQAVDLMNQ PLDKVLEQAR RHSWVNLSRA PTPRTQGQKT PPPDPVGTYN PACALALNEA
   301  KRLLVESKDT LVEMAKNEVD VREQQLQISD RVCASLAQKA SETLELKERL NMTLGLMRGT
   361  ILRCTKYNQE LYTTHGLIKG PLSKVHLETA EKLDRPLVRM YQRHVGTQLP EAARLAQGTD
   421  KLQCHITYLE KNLDELLATH KNLSWGLNCK NIGHEVDGNV VRLRLRQRQP HVCYEQAQRL
   481  VKDWDPRTPP PRSKSSADP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
pancreas: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 185 nCPM
late primary spermatocytes: 159 nCPM
late spermatids: 34 nCPM
sertoli cells: 2.6 nCPM
hematopoietic stem cells: 1 nCPM
other brain neurons: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tektin-like
Tektin family
Tektin-like protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKTL1 as an antibody target. Whether an autoantibody or antibody against TEKTL1 could matter depends on whether native TEKTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKTL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEKTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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