Seroatlas · Human Serome Atlas

TEKTIP1

Tektin bundle-interacting protein 1

Also known as: C19orf71, LOC100128569, TKTI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCJ1
Gene: TEKTIP1
Ensembl: ENSG00000183397
Chromosome: 19
Canonical length: 209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to be located in axonemal microtubule. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>A6NCJ1|TEKTIP1
     1  MQTLRQEAAR PCIPSGTLEA SFPAPLYSDD YLSLEGSRWP PAIRQATRWK YTPMGRDAAG
    61  QLWYTGLTNS DAWEAWYNLP RAPASPFREA YNRWHSCYQH RECSMPSAYT QHLRETAWHD
   121  PIVPAQYQAP STRWGSALWK DRPIRGKEYV LNRNRYGVEP LWRASDYVPS LSAPQRPPGT
   181  TQNYREWVLE PYCPSTCQRS PPSLTPTPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKTIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

testis: 48 nTPM
skin: 13 nTPM
salivary gland: 12 nTPM
cerebellum: 12 nTPM
bone marrow: 10 nTPM
spleen: 9.6 nTPM

Single-cell type

early spermatids: 789 nCPM
late spermatids: 538 nCPM
late primary spermatocytes: 87 nCPM
retinal amacrine cells: 15 nCPM
medullary thymic epithelial cells: 12 nCPM
retinal horizontal cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 56 nTPM
white matter: 46 nTPM
cerebral cortex: 39 nTPM
hypothalamus: 36 nTPM
thalamus: 33 nTPM
hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tektin bundle-interacting protein 1
Tektin bundle interacting protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKTIP1 as an antibody target. Whether an autoantibody or antibody against TEKTIP1 could matter depends on whether native TEKTIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKTIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEKTIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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