Seroatlas · Human Serome Atlas

TEDDM1

Transmembrane epididymal protein 1

Also known as: EDDM9, Epdd1, HE9, TEDM1_HUMAN, TMEM45C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T9Z0
Gene: TEDDM1
Ensembl: ENSG00000203730
Chromosome: 1
Canonical length: 273 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q5T9Z0|TEDDM1
     1  MILKGCLLYP LCSPRNKQRC ARLWKIAYGG LLKIVTGSLL TFYVVLCLDG GMVLMRKQVP
    61  SRFMYPKEWQ HLTMFILLTL NGCVDFMSKN VLPQRCVGLE KGTLVLIIYE LLLLMVSHVK
   121  DSEGVELHVY SLLILVVFLL LLVLTAELWA PNMCHLQLME TFLILMMGSW LMQAGFILYR
   181  PVSGYPWQDD DISDIMFVTT FFCWHVMINA SFLLGIYGFS SFWYHCFRPS LKLTGPKEAP
   241  YYASTPGPLY KLLQEVEQSE KEDQALLLPK SSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEDDM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 544 nTPM

Expression across tissuesHPA

Tissue

epididymis: 544 nTPM
seminal vesicle: 1 nTPM
testis: 0.4 nTPM
skeletal muscle: 0.3 nTPM
cerebellum: 0.2 nTPM
bone marrow: 0.1 nTPM

Single-cell type

epididymal principal cells: 822 nCPM
epididymal basal cells: 9.6 nCPM
epididymal efferent duct absorptive cells: 9.5 nCPM
epididymal clear cells: 4.1 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM
mast cells: 1.2 nCPM

Immune cell

neutrophil: 0.8 nTPM
basophil: 0.2 nTPM
eosinophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 3.9 nTPM
amygdala: 2.2 nTPM
basal ganglia: 1.9 nTPM
cerebral cortex: 1.9 nTPM
white matter: 1.8 nTPM
medulla oblongata: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEDDM1 as an antibody target. Whether an autoantibody or antibody against TEDDM1 could matter depends on whether native TEDDM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEDDM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEDDM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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