Seroatlas · Human Serome Atlas

TDRG1

Testis development-related protein 1

Also known as: TDRG1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3Y452
Gene: TDRG1
Canonical length: 100 aa

OverviewNCBI Gene

No narrative summary is available for TDRG1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q3Y452|TDRG1
     1  MKRREAVCAH RHFLGTGKPP HPLGRSIPVE PCPGLPAFAE VDLLSLLVPI KISSTPPSGS
    61  RLDPQIASSA FPGLGSLGGQ DSSGSLVQRA SCELESPYEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRG1 as an antibody target. Whether an autoantibody or antibody against TDRG1 could matter depends on whether native TDRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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