Seroatlas · Human Serome Atlas

TCTE1

Dynein regulatory complex subunit 5

Also known as: D6S46, DRC5, DRC5_HUMAN, FAP155, MGC33600

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JU00
Gene: TCTE1
Ensembl: ENSG00000146221
Chromosome: 6
Canonical length: 501 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol,Mid piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q5JU00|TCTE1
     1  MQDTVTTSAL LDPSHSSVST QDNSSTGGHT SSTSPQLSKP SITPVPAKSR NPHPRANIRR
    61  MRRIIAEDPE WSLAIVPLLT ELCIQHIIRN FQKNPILKQM LPEHQQKVLN HLSPDLPLAV
   121  TANLIDSENY WLRCCMHRWP VCHVAHHGGS WKRMFFERHL ENLLKHFIPG TTDPAVILDL
   181  LPLCRNYVRR VHVDQFLPPV QLPAQLRPGD QSDSGSEGEM EEPTVDHYQL GDLVAGLSHL
   241  EELDLVYDVK DCGMNFEWNL FLFTYRDCLS LAAAIKACHT LKIFKLTRSK VDDDKARIII
   301  RSLLDHPVLE ELDLSQNLIG DRGARGAAKL LSHSRLRVLN LANNQVRAPG AQSLAHALAH
   361  NTNLISLNLR LNCIEDEGGQ ALAHALQTNK CLTTLHLGGN ELSEPTATLL SQVLAINTTL
   421  TSINLSCNHI GLDGGKQLLE GMSDNKTLLE FDLRLSDVAQ ESEYLIGQAL YANREAARQR
   481  ALNPSHFMST ITANGPENSV G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCTE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
fallopian tube: 14 nTPM
cerebellum: 7.9 nTPM
hippocampal formation: 4.6 nTPM
amygdala: 3.3 nTPM
cerebral cortex: 3 nTPM

Single-cell type

late spermatids: 535 nCPM
early spermatids: 182 nCPM
late primary spermatocytes: 84 nCPM
respiratory ciliated cells: 57 nCPM
fallopian tube ciliated cells: 34 nCPM
ependymal cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 16 nTPM
midbrain: 9.6 nTPM
medulla oblongata: 9.4 nTPM
spinal cord: 8.4 nTPM
amygdala: 5.7 nTPM
cerebral cortex: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

sperm flagellum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCTE1 as an antibody target. Whether an autoantibody or antibody against TCTE1 could matter depends on whether native TCTE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCTE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCTE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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