Seroatlas · Human Serome Atlas

TCTA

T-cell leukemia translocation-altered gene protein

Also known as: TCTA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57738
Gene
TCTA
Ensembl
ENSG00000145022
Chromosome
3
Canonical length
103 aa
Protein class
Disease related genes, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>P57738|TCTA
     1  MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY
    61  GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 65 nTPM
  • kidney: 60 nTPM
  • pituitary gland: 52 nTPM
  • adrenal gland: 50 nTPM
  • spinal cord: 50 nTPM
  • choroid plexus: 49 nTPM

Single-cell type

  • colonocytes: 79 nCPM
  • epididymal principal cells: 72 nCPM
  • platelets: 66 nCPM
  • enterocytes: 64 nCPM
  • cytotrophoblasts: 42 nCPM
  • goblet cells: 38 nCPM

Immune cell

  • non-classical monocyte: 52 nTPM
  • intermediate monocyte: 37 nTPM
  • eosinophil: 25 nTPM
  • NK-cell: 25 nTPM
  • total PBMC: 24 nTPM
  • basophil: 22 nTPM

Brain region

  • pons: 46 nTPM
  • thalamus: 46 nTPM
  • midbrain: 45 nTPM
  • basal ganglia: 45 nTPM
  • medulla oblongata: 45 nTPM
  • hypothalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • T-cell leukemia translocation-altered gene protein
  • T-cell leukemia translocation-altered

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCTA as an antibody target. Whether an autoantibody or antibody against TCTA could matter depends on whether native TCTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCTA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCTA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...