TCN1

Protein identityUniProt · HPA

UniProt accession

P20061

Gene

TCN1

Ensembl

ENSG00000134827

Chromosome

11

Canonical length

433 aa

Protein class

Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>P20061|TCN1
     1  MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR GTSAVNVVLS
    61  LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL ALGVCRNAEE NLIYDYHLID
   121  KLENKFQAEI ENMEAHNGTP LTNYYQLSLD VLALCLFNGN YSTAEVVNHF TPENKNYYFG
   181  SQFSVDTGAM AVLALTCVKK SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN
   241  TFSTGEAMQA LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL
   301  DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV TVLNGSVFLS
   361  VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT YWELLSGGEP LSQGAGSYVV
   421  RNGENLEVRW SKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

817 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TCN1.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Transcobalamin I deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.72

gnomAD pLI

0

gnomAD missense Z

-1.08

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cobalamin transport
• cobalt ion transport

Molecular functions

• cargo receptor ligand activity
• cobalamin binding
• molecular sequestering activity

Cellular components

• extracellular region
• extracellular space
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Cobalamin (vitamin B12)-binding protein
• Eukaryotic Cobalamin Transport
• Eukaryotic cobalamin-binding protein
• Transcobalamin-like, C-terminal domain
• Domain of unknown function (DUF4430)

KeywordsUniProt

• Cobalt
• Cobalt transport
• Disulfide bond
• Glycoprotein
• Ion transport
• Secreted
• Signal
• Transport