Seroatlas · Human Serome Atlas

TCL1B

T-cell leukemia/lymphoma protein 1B

Also known as: TCL1B_HUMAN, TML1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95988
Gene: TCL1B
Ensembl: ENSG00000213231
Chromosome: 14
Canonical length: 128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>O95988|TCL1B
     1  MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS QGSRYEPSIT
    61  VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD SSFWEIADHG QIDSMEQLVL
   121  TYQPERKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCL1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

testis: 2.5 nTPM
tonsil: 2.3 nTPM
lymph node: 2 nTPM
bone marrow: 1.1 nTPM
placenta: 0.8 nTPM
spleen: 0.7 nTPM

Single-cell type

syncytiotrophoblasts: 2.5 nCPM
proximal tubule cells: 1.9 nCPM
distal convoluted tubule cells: 0.4 nCPM
papillary tip epithelial cells: 0.4 nCPM
undifferentiated spermatogonia: 0.4 nCPM
nk-cells: 0.3 nCPM

Immune cell

naive B-cell: 12 nTPM
plasmacytoid DC: 6.2 nTPM
neutrophil: 0.3 nTPM
NK-cell: 0.3 nTPM
total PBMC: 0.3 nTPM
basophil: 0 nTPM

Brain region

white matter: 2.6 nTPM
basal ganglia: 2.1 nTPM
medulla oblongata: 1.9 nTPM
pons: 1.8 nTPM
midbrain: 1.5 nTPM
thalamus: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.01
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCL1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCL1B as an antibody target. Whether an autoantibody or antibody against TCL1B could matter depends on whether native TCL1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCL1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCL1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...