TCHHL1

Protein identityUniProt · HPA

UniProt accession

Q5QJ38

Gene

TCHHL1

Ensembl

ENSG00000182898

Chromosome

1

Canonical length

904 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nuclear membrane,Nucleoli

OverviewNCBI Gene

This gene belongs to the S100 fused-type protein (SFTP) gene family, and is located in a cluster of SFTP genes on chromosome 1q21. Several members of this family have been implicated in the development of complex skin disorders. This gene is evolutionarily conserved; its expression appears to be hair-specific and spatially restricted within the distal inner root sheath of the hair follicle. It thus may have an important role in hair morphogenesis. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q5QJ38|TCHHL1
     1  MPQLLRNVLC VIETFHKYAS EDSNGATLTG RELKQLIQGE FGDFFQPCVL HAVEKNSNLL
    61  NIDSNGIISF DEFVLAIFNL LNLCYLDIKS LLSSELRQVT KPEKEKLDDV DVQATTGDGQ
   121  WTVGTSPTQE KRMLPSGMAS SSQLIPEESG AVGNNRVDPW REAKTHNFPG EASEHNDPKN
   181  KHLEGDEQSQ EVAQDIQTTE DNEGQLKTNK PMAGSKKTSS PTERKGQDKE ISQEGDEPAR
   241  EQSVSKIRDQ FGEQEGNLAT QSSPPKEATQ RPCEDQEVRT EKEKHSNIQE PPLQREDEPS
   301  SQHADLPEQA AARSPSQTQK STDSKDVCRM FDTQEPGKDA DQTPAKTKNL GEPEDYGRTS
   361  ETQEKECETK DLPVQYGSRN GSETSDMRDE RKERRGPEAH GTAGQKERDR KTRPLVLETQ
   421  TQDGKYQELQ GLSKSKDAEK GSETQYLSSE GGDQTHPELE GTAVSGEEAE HTKEGTAEAF
   481  VNSKNAPAAE RTLGARERTQ DLAPLEKQSV GENTRVTKTH DQPVEEEDGY QGEDPESPFT
   541  QSDEGSSETP NSLASEEGNS SSETGELPVQ GDSQSQGDQH GESVQGGHNN NPDTQRQGTP
   601  GEKNRALEAV VPAVRGEDVQ LTEDQEQPAR GEHKNQGPGT KGPGAAVEPN GHPEAQESTA
   661  GDENRKSLEI EITGALDEDF TDQLSLMQLP GKGDSRNELK VQGPSSKEEK GRATEAQNTL
   721  LESLDEDNSA SLKIQLETKE PVTSEEEDES PQELAGEGGD QKSPAKKEHN SSVPWSSLEK
   781  QMQRDQEPCS VERGAVYSSP LYQYLQEKIL QQTNVTQEEH QKQVQIAQAS GPELCSVSLT
   841  SEISDCSVFF NYSQASQPYT RGLPLDESPA GAQETPAPQA LEDKQGHPQR ERLVLQREAS
   901  TTKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCHHL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

0.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0.58

gnomAD missense Z

-0.54

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• transition metal ion binding

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• S-100
• S-100/ICaBP type calcium binding domain
• Trichohyalin-like protein 1