Seroatlas · Human Serome Atlas

TCF19

Transcription factor 19

Also known as: SC1, TCF19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y242
Gene: TCF19
Ensembl: ENSG00000137310
Chromosome: 6
Canonical length: 345 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9Y242|TCF19
     1  MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL
    61  HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM
   121  FQQVRVKPQD FAAITIPRSR GEARVGAGFR PMLPSQGAPQ RPLSTFSPAP KATLILNSIG
   181  SLSKLRPQPL TFSPSWGGPK SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP
   241  PENPPPVLME PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
   301  QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

esophagus: 12 nTPM
spleen: 9 nTPM
skin: 8.6 nTPM
cerebellum: 8 nTPM
lymph node: 7.8 nTPM
cervix: 7.7 nTPM

Single-cell type

loop of henle epithelial cells: 6.2 nCPM
papillary tip epithelial cells: 5.3 nCPM
renal collecting duct principal cells: 5 nCPM
paneth cells: 3.9 nCPM
distal convoluted tubule cells: 3.1 nCPM
renal connecting tubule cells: 3 nCPM

Immune cell

T-reg: 2.2 nTPM
MAIT T-cell: 1.7 nTPM
memory CD8 T-cell: 1.5 nTPM
naive CD4 T-cell: 1.3 nTPM
naive B-cell: 1.1 nTPM
gdT-cell: 1 nTPM

Brain region

cerebellum: 1.2 nTPM
thalamus: 1.2 nTPM
pons: 0.8 nTPM
basal ganglia: 0.7 nTPM
medulla oblongata: 0.7 nTPM
white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCF19 as an antibody target. Whether an autoantibody or antibody against TCF19 could matter depends on whether native TCF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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